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Nuno Joao Silva

Development and validation of magnetic nanobeads as hyperthermia agents and thermometers in imaging

 At the home institution, I’m engaged in the development of multifunctional nanobeads and ferrofluids for magnetic hyperthermia and thermometry. This work is being developed in collaboration with the Spanish Host Institution [Pinol et al. ACSNano 9, 3134 (2015)]. At the other Host institution, the local group is engaged in the development of nanoparticles for magnetic hyperthermia and Magnetic Resonance Imaging (MRI) [Orlando et al. Nano Lett. 14, 3959 (2014)]. During this STSM we joined the efforts of the three teams aiming at the development of nanobeads for Hyperthermia/Thermometry/Imaging. The synthesis was developed at the home institution, based on typical thermodecomposition methods followed by a successful phase transfer to aqueous media. The hyperthermia and thermometry studies were performed at the Spanish host institution and the relaxivity studies were performed at the Italian host institution. Without disclosing details, I can say that the results were encouraging and gave us important clues on how to improve the magnetic properties of the nanobeads and on how to tune the structural properties in order to achieve this improvement. We are now improving the synthesis procedures aiming this tuning and we hope to have good news to report soon.