Participating Countries:

	COST is supported by the EU Framework Programme Horizon 2020
	This website is supported by COST

David Cabrera

Test and validation of a prototype of AC magnetic field generator for magnetic hyperthermia

The present Shot Term Scientific Mission aimed to test and validate a prototype of Alternating Magnetic Field Generator (amfG) for in vitro magnetic hyperthermia experiments. Such system, with a working range of 10-300kHz and field intensities up to 50 mT, features remarkable advantages compared with current commercial equipments of which should be highlighted the portability, friendly-use interface and an accurate control of cell media thermal conditions. The amfG is based on a ferrite core wired with Litz type wire liquid cooled and automatized via software. Its arrangement permits placing 4 wells Petri dishes inside, applying a quasi-uniform magnetic field on a single well where cells have been previously seeded. The University Hospital of Jena group led by Prof. Ingrid Hilger provided us a suitable framework for testing our prototype, performing during the stay two in-vitro magnetic hyperthermia experiments with MCF-7 cell line as well as subsequent viability and complementary staining test (Prussian Blue). In addition, UHJ research members showed a deep interest on the prototype capabilities for hyperthermia experiments to track the thermal stress on the cell morphology. Just to conclude, from a personal point of view, the present Mission represented for me an inflection point for my PhD work due to the acquired abilities in cell biology during my stay in UHJ will facilitate to achieve the goals of my thesis.

Poster/Oral presentation(s) /Conference abstract(s) originating from this mission