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1/21/2018 (Added to site)
Author(s): David Colecchia, Elena Nicolato, Costanza Ravagli, Paola Faraoni, Angela Strambi, Matteo Rossi, Saer Doumett, Elisa Mosconi, Erica Locatelli, Mauro Comes Franchini, Manuela Balzi, Giovanni Baldi, Pasquina Marzola and Mario Chiariello

EGFR-Targeted Magnetic Nanovectors Recognize, in Vivo, Head and Neck Squamous Cells Carcinoma-Derived Tumors

Journal: ACS Medicinal Chemistry Letters
DOI: 10.1021/acsmedchemlett.7b00278
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 Head and neck squamous cell carcinomas (HNSCC) are a diverse group of tumors with high morbidity and mortality that have remained mostly unchanged over the past decades. The epidermal growth factor receptor (EGFR) is often overexpressed and activated in these tumors and strongly contributes to their pathogenesis. Still, EGFR-targeted therapies such as monoclonal antibodies and kinase inhibitors have demonstrated only limited improvements in the clinical outcome of this disease. Here, we take advantage of the extraordinary affinity of EGF for its cognate receptor to specifically target magnetite-containing nanoparticles to HNSCC cells and mediate, in vitro, their cellular upload. On the basis of this, we show efficient accumulation, in vivo, of such nanoparticles in subcutaneous xenograft tumor tissues in sufficient amounts to be able to mediate visualization by magnetic resonance imaging. Overall, our EGF-coated nanosystem may warrant, in the near future, novel and very efficient theranostic approaches to HNSCC.

Link:

pubs.acs.org/doi/pdf/10.1021/acsmedchemlett.7b00278



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